Oak stands are among the most economically valuable stands and they have been considered resilient against adverse biotic factors for a long time. A breaking point occurred in the 1980’s when mass oak dieback was recorded in Slovakia. Currently, the negative trend in the state of oak stands is aggravated by the expansion of the yellow mistletoe and the growing population of the oak bark beetle. The goal of our work was to assess the influence of these major biotic factors on the state of oak stands and the suitability of measures to control their abundance within a model area in Považský Inovec mountains. We investigated the influence of yellow mistletoe on oaks within two permanent study sites in LS Duchonka. At the first site, we chose 150 trees divided into three categories: 1. attacked, 2. non-attacked and 3. mechanically treated oaks. At the second site, we chose 30 trees in total, also divided into three categories: 1. attacked at stand edge, 2. attacked within stand interior and 3. mechanically treated oaks. We measured increases in thickness of each oak every year. We monitored physiological processes, water potencial of oaks and nutrient content of attacked and non-attacked trees. We also assessed the influence of tree position within the stand on the abundance and severity of yellow mistletoe attack. The bionomy, population density and maternal gallery lenghth of the oak bark beetle was monitored on oak trap trees, which were founded each month during the growing season. The repelent influence of emitters used abroad was monitored on oak samples and, in the second year, also on oak trap trees. We found that oaks attacked by yellow mistletoe had significantly decreased assimilation speed and lower water potential than non-attacked oaks. The abundance and severity of yellow mistletoe attack increased with tree age. Mechanical removal of yellow mistletoe only partially resulted in the acceleration of increases in thickness, markedly in the 1st and 3rd year. The yellow mistletoe negatively influences the health status of oak stands. Presence of yellow mistletoe negatively influences the water balance of oaks and becomes an important stress factor during a period of lower precipitation. Severe attack results in oak crown breakdown and gradual dieback of attacked individuals, especially in older stands. The yellow mistletoe also negatively influences the height and thickness increments of oaks. Oak trap trees were attractive during almost the entire observation period. Long-term warm and dry weather increased their attractivity. Warm and dry periods during summer stimulate the founding of a second generation of the oak bark beetle. A 1°C increase in temperature increased trap tree occupation by 7 %. The trap trees need to be removed in the same year when they were founded. The combination of 44% (-)-α-pinene, 19% (-)-β-Pinene, 10% (+)-3-Carene, 18% (+)-Limonene, 9% α-Terpenolene in tested emitters had a repellent effect. The emitter had a repellent effect up to 2/3 of trunk height. The oak bark beetle population is consistently high during the entire growing season. Climatic conditions also contribute to population size. Currently, we observe low precipitation during summer each year, which markedly weakens oaks and provides suitable conditions for the spread of bark and wood-boring insects. Suitable climatic conditions, along with neglected forest hygiene, may cause increased oak mortality. We suppose that investigating the influence and consequences of key health factors will contribute to more intense and systematic protection of native oaks in Považský Inovec against various adverse biotic factors, thus preventing the breakdown of native oak communities.